NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in every living cell and a substrate for the PARP-1 and sirtuin enzyme families. It sits at the center of redox reactions and cellular energy metabolism, which makes it one of the most widely referenced compounds in cellular-aging and mitochondrial research.

In the laboratory, NAD+ is studied for its roles in DNA repair, SIRT1 and SIRT3 activation, mitochondrial biogenesis, and the broader set of pathways associated with the hallmarks of cellular aging. Researchers use it in in-vitro systems to examine how coenzyme availability influences these interconnected metabolic and repair mechanisms. All material supplied by The Forge is intended strictly for in-vitro laboratory research and never for human or animal use.

NAD+ is offered in three quantities — 100mg, 500mg, and 1000mg — because coenzyme research spans a wide range of preparation volumes, and a larger vial is more economical for higher-throughput work while a smaller vial suits focused studies. Every vial is lyophilized and third-party lab tested at ≥98% purity by HPLC, with a Certificate of Analysis available on request by email. Store lyophilized vials cool, dry, and out of direct light; refrigeration is recommended for longer-term storage, and repeated temperature swings should be avoided to preserve integrity.